Resilience to aging in the regeneration-capable flatwormMacrostomum lignano
نویسندگان
چکیده
منابع مشابه
Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.
The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts. This set of unique properties makes many flatworms attractive organisms for studying the evolution of pathways involved in tissue self-renewal, cell-fate spec...
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متن کاملThe Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano.
The Hippo pathway orchestrates activity of stem cells during development and tissue regeneration and is crucial for controlling organ size. However, roles of the Hippo pathway in highly regenerative organisms, such as flatworms, are unknown. Here we show that knockdown of the Hippo pathway core genes in the flatworm Macrostomum lignano affects tissue homeostasis and causes formation of outgrowt...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2018
ISSN: 1474-9718
DOI: 10.1111/acel.12739